Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Obesity is a major health problem, and many family-based studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing BMI in 573 pedigrees from the U.K. We identified genome-wide significant linkage (logarithm of odds = 3....
Main Authors: | Groves, C, Zeggini, E, Walker, M, Hitman, G, Levy, J, O'Rahilly, S, Hattersley, A, McCarthy, M, Wiltshire, S |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2006
|
Similar Items
-
Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
by: Wiltshire, S, et al.
Published: (2002) -
No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
by: Frayling, T, et al.
Published: (2000) -
Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs
by: Groves, C, et al.
Published: (2002) -
Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
by: Groves, C, et al.
Published: (2003) -
Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24.
by: McCarthy, M, et al.
Published: (2001)