Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Obesity is a major health problem, and many family-based studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing BMI in 573 pedigrees from the U.K. We identified genome-wide significant linkage (logarithm of odds = 3....
Κύριοι συγγραφείς: | Groves, C, Zeggini, E, Walker, M, Hitman, G, Levy, J, O'Rahilly, S, Hattersley, A, McCarthy, M, Wiltshire, S |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2006
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
ανά: Wiltshire, S, κ.ά.
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Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs
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Έκδοση: (2002) -
No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
ανά: Frayling, T, κ.ά.
Έκδοση: (2000) -
Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24.
ανά: McCarthy, M, κ.ά.
Έκδοση: (2001) -
Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
ανά: Groves, C, κ.ά.
Έκδοση: (2003)