Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation.

Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation.

Metallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showe...

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Κύριοι συγγραφείς: Hanke, T, Tyers, M, Harley, C
Μορφή: Journal article
Γλώσσα:English
Έκδοση: 1988
Περιγραφή
Περίληψη:Metallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showed similar basal levels of MT RNA with significant induction following exposure to Cd2+ but not activators of PKC. MT RNA did not correlate with growth state or with known levels of PKC activity, thus our data do not support a role for MT in HL-60 differentiation or for PKC in MT expression.

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