Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.
It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826295639047143424 |
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| author | Wright, J Brumme, Z Julg, B van der Stok, M Mncube, Z Gao, X Carlson, J Goulder, P Walker, B Brockman, M Ndung'u, T |
| author_facet | Wright, J Brumme, Z Julg, B van der Stok, M Mncube, Z Gao, X Carlson, J Goulder, P Walker, B Brockman, M Ndung'u, T |
| author_sort | Wright, J |
| collection | OXFORD |
| description | It is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles and lower replication capacity, suggesting no significant HIV-1 attenuation by HLA class II-restricted Gag-specific CD4(+) T cell immune pressure. |
| first_indexed | 2024-03-07T04:04:08Z |
| format | Journal article |
| id | oxford-uuid:c5904fae-de06-4710-8a5c-997251a3ba77 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:04:08Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:c5904fae-de06-4710-8a5c-997251a3ba772022-03-27T06:31:57ZLack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c5904fae-de06-4710-8a5c-997251a3ba77EnglishSymplectic Elements at Oxford2012Wright, JBrumme, ZJulg, Bvan der Stok, MMncube, ZGao, XCarlson, JGoulder, PWalker, BBrockman, MNdung'u, TIt is unknown whether favorable HLA class II alleles may attenuate HIV-1 through selection pressure in a manner similar to that of protective HLA class I alleles. We investigated the relationship between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. No associations were found between individual alleles and lower replication capacity, suggesting no significant HIV-1 attenuation by HLA class II-restricted Gag-specific CD4(+) T cell immune pressure. |
| spellingShingle | Wright, J Brumme, Z Julg, B van der Stok, M Mncube, Z Gao, X Carlson, J Goulder, P Walker, B Brockman, M Ndung'u, T Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. |
| title | Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. |
| title_full | Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. |
| title_fullStr | Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. |
| title_full_unstemmed | Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. |
| title_short | Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals. |
| title_sort | lack of association between hla class ii alleles and in vitro replication capacities of recombinant viruses encoding hiv 1 subtype c gag protease from chronically infected individuals |
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