Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity

Receptor phosphorylation is thought to be tightly regulated because phosphorylated receptors initiate signaling cascades leading to cellular activation. The T cell antigen receptor (TCR) on the surface of T cells is phosphorylated by the kinase Lck and dephosphorylated by the phosphatase CD45 on mul...

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Detalhes bibliográficos
Main Authors: Mukhopadhyay, H, Cordoba, S, Maini, P, van der Merwe, A, Dushek, O
Formato: Journal article
Publicado em: PLOS 2013