Pharmacological inhibition of ATR can block autophagy through an ATR-independent mechanism

Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a potential link between ATR inhibition and the autophagy process in esophageal cancer cells using four ATR i...

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Bibliographic Details
Main Authors: Bowler, E, Skwarska, A, Wilson, JD, Ramachandran, S, Bolland, H, Easton, A, Ostheimer, C, Hwang, M-S, Leszczynska, KB, Conway, SJ, Hammond, EM
Format: Journal article
Language:English
Published: Cell Press 2020