Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

OBJECTIVES: Genome-wide association studies have dramatically increased the number of common genetic variants that are robustly associated with type 2 diabetes. A possible clinical use of this information is to identify individuals at high risk of developing the disease, so that preventative measur...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Lango, H, Palmer, C, Morris, A, Zeggini, E, Hattersley, A, McCarthy, M, Frayling, T, Weedon, M
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2008

Παρόμοια τεκμήρια

Large-scale replication typing of modest signals from genome-wide association studies identifies additional type 2 diabetes susceptibility variants in the IGF2BP2 and VEGFA genes
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Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
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A common variant in the FTO gene region is associated with BMI in the general population and predisposes to adult and childhood obesity
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A powerful approach to sub-phenotype analysis in population-based genetic association studies.
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
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Common variants in WFS1 confer risk of type 2 diabetes.
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No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
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Extended analysis of genome-wide scans provides clues about novel common and rare susceptibility loci for type 2 diabetes
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Common variation in the LMNA gene increases susceptibility to type 2 diabetes
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Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
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Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
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The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
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Studies of genome-wide association data support a genetic overlap between type 2 diabetes and prostate cancer
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Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
ανά: Patel, S, κ.ά.
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
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Genome-wide association scan allowing for epistasis in type 2 diabetes.
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Biological pathway analysis for type 2 diabetes using genome-wide association data
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Common variation in the FTO (fused toes) gene is strongly associated with adiposity measures in the northern finnish birth cohort of 1966
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Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
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Type 2 diabetes risk alleles are associated with reduced size at birth.
ανά: Freathy, R, κ.ά.
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Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
ανά: Mitchell, S, κ.ά.
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Genome-wide association data highlight an aetiological role for disturbances in cyclin-dependent kinase pathways in type 2 diabetes
ανά: Timpson, N, κ.ά.
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Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
ανά: Zeggini, E, κ.ά.
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Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
ανά: Freathy, R, κ.ά.
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Identifying susceptibility variants for type 2 diabetes.
ανά: Zeggini, E, κ.ά.
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Is Modest Fashion Modest?
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Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
ανά: Southam, L, κ.ά.
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The functional "KL-VS" variant of <it>KLOTHO </it>is not associated with type 2 diabetes in 5028 UK Caucasians
ανά: Walker Mark, κ.ά.
Έκδοση: (2006-06-01)

Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
ανά: Gloyn, A, κ.ά.
Έκδοση: (2005)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
ανά: Freathy, R, κ.ά.
Έκδοση: (2006)

Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
ανά: Timpson, N, κ.ά.
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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
ανά: Gloyn, A, κ.ά.
Έκδοση: (2003)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
ανά: Gloyn, A, κ.ά.
Έκδοση: (2003)