Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.

Antzeko izenburuak

• Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.
  nork: Magistrelli, G, et al.
  Argitaratua: (1999)
• Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling.
  nork: Di Bartolo, V, et al.
  Argitaratua: (1999)
• INTERACTION OF HUMAN P56LCK SH2 DOMAIN WITH THE ZAP-70 TYROSINE KINASE
  nork: Acuto, O, et al.
  Argitaratua: (1994)
• T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.
  nork: Magnan, A, et al.
  Argitaratua: (2001)
• Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation
  nork: Salek, M, et al.
  Argitaratua: (2013)