Development of models of active ion transport for whole-cell modelling: cardiac sodium–potassium pump as a case study

<p>This study presents a method for the reduction of biophysically-based kinetic models for the active transport of ions. A lumping scheme is presented which exploits the differences in timescales associated with fast and slow transitions between model states, while maintaining the thermodynam...

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Bibliographic Details
Main Authors: Smith, NP, Crampin, EJ
Format: Journal article
Language:English
Published: Elsevier 2004