Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

The JmjC oxygenases catalyze the N-demethylation of N(ε)-methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozi...

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Bibliographic Details
Main Authors:	Rose, N, Woon, E, Tumber, A, Walport, L, Chowdhury, R, Li, X, King, O, Lejeune, C, Ng, S, Krojer, T, Chan, M, Rydzik, A, Hopkinson, R, Che, K, Daniel, M, Strain-Damerell, C, Gileadi, C, Kochan, G, Leung, I, Dunford, J, Yeoh, K, Ratcliffe, P, Burgess-Brown, N, von Delft, F, Muller, S
Format:	Journal article
Language:	English
Published:	2012

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

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