Maintenance of CD4 T cell fitness through regulation of Foxo1

Foxo transcription factors play an essential role in regulating specialized lymphocyte functions, and in maintenance of T cell quiescence. Here, we used a system where Foxo1 transcription factor activity, normally terminated upon cell activation, cannot be silenced and show that enforcing Foxo1 acti...

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Bibliographic Details
Main Authors: Newton, R, Shrestha, S, Sullivan, J, Yates, K, Compeer, E, Ron-Harel, N, Blazar, B, Bensinger, S, Haining, W, Dustin, M, Campbell, D, Chi, H, Turka, L
Format: Journal article
Published: Nature Publishing Group 2018