Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides.

Factor I (fI) is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. Human fI circulates in plasma as a heavily N-glycosylated (25-27% w/w) heterodimer composed of two disulphide linked chains, each carrying three N-linked oligosaccharide chains. I...

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Bibliographic Details
Main Authors: Tsiftsoglou, SA, Arnold, J, Roversi, P, Crispin, MD, Radcliffe, C, Lea, S, Dwek, R, Rudd, P, Sim, R
Format: Journal article
Language:English
Published: 2006