Analysis of a gain-of-function mutation that produces a new transcriptional unit in the α-globin locus
<p>The expression of the human α-globin locus is regulated by a set of well characterized enhancer elements. Mutations in the α-globin protein coding genes or their regulatory elements can cause a form of anaemia called α-thalassemia which results from the downregulation of α-globin in red blo...
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2017
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