Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates.

Fibronectin (FN) forms fibrillar networks coupling cells to the extracellular matrix. The formation of FN fibrils, fibrillogenesis, is a tightly regulated process involving the exposure of cryptic binding sites in individual FN type III (FN-III) repeats presumably exposed by mechanical tension. The...

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Bibliographic Details
Main Authors: Gao, M, Craig, D, Lequin, O, Campbell, I, Vogel, V, Schulten, K
Format: Journal article
Language:English
Published: 2003