Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic factor; however, the mechanistic basis for this is po...

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Bibliographic Details
Main Authors:	Hannigan, A, Smith, P, Kalna, G, Lo Nigro, C, Orange, C, O'Brien, D, Shah, R, Syed, N, Spender, L, Herrera, B, Thurlow, J, Lattanzio, L, Monteverde, M, Maurer, M, Buffa, F, Mann, J, Chu, D, West, C, Patridge, M, Oien, K, Cooper, J, Frame, M, Harris, A, Hiller, L, Nicholson, L
Format:	Journal article
Language:	English
Published:	2010

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

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