Response of human lung fibroblast cells to stimulation by endothelin-1: Involvement of ras/MEK/ERK and PI3 kinase

Geahča maid

• Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
  Dahkki: Xu, S, et al.
  Almmustuhtton: (2004)
• Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
  Dahkki: Shi-Wen, X, et al.
  Almmustuhtton: (2007)
• Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
  Dahkki: Shi-wen, X, et al.
  Almmustuhtton: (2007)
• Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
  Dahkki: Shi-Wen, X, et al.
  Almmustuhtton: (2004)
• Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.
  Dahkki: Shi-Wen, X, et al.
  Almmustuhtton: (2001)