Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

Celý popis

Podrobná bibliografie
Hlavní autoři: Baker, A, Huang, W, Wang, X, Jansen, M, Ma, X, Kim, J, Anderson, C, Wu, X, Pan, L, Su, N, Luo, Y, Domingo, E, Heide, T, Sottoriva, A, Lewis, A, Beggs, A, Wright, N, Rodriguez-Justo, M, Park, E, Tomlinson, I, Graham, T
Médium: Journal article
Jazyk:English
Vydáno: Nature Publishing Group 2017

Podobné jednotky

Podobné jednotky