Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

書誌詳細
主要な著者:	Baker, A, Huang, W, Wang, X, Jansen, M, Ma, X, Kim, J, Anderson, C, Wu, X, Pan, L, Su, N, Luo, Y, Domingo, E, Heide, T, Sottoriva, A, Lewis, A, Beggs, A, Wright, N, Rodriguez-Justo, M, Park, E, Tomlinson, I, Graham, T
フォーマット:	Journal article
言語:	English
出版事項:	Nature Publishing Group 2017

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