PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

mRNA modifications play important roles in regulating gene expression. One of the most abundant mRNA modifications is N6,2-O-dimethyladenosine (m6Am). Here, we demonstrate that m6Am is an evolutionarily conserved mRNA modification mediated by the Phosphorylated CTD Interacting Factor 1 (PCIF1), whic...

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Bibliografske podrobnosti
Main Authors: Sendinc, E, Valle-Garcia, D, Dhall, A, Chen, H, Henriques, T, Navarrete-Perea, J, Sheng, W, Gygi, SP, Adelman, K, Shi, Y
Format: Journal article
Jezik:English
Izdano: Elsevier 2019