Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.

Soluble tumour necrosis factor receptors (sTNF-R) are up-regulated at sites of chronic inflammation such as rheumatoid synovial joints. The p75 sTNF-R is the more abundant, suggesting an important role for this TNF inhibitor in regulating TNF bioactivity in vivo. As the precise cellular source of th...

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Bibliographic Details
Main Authors: Cope, A, Aderka, D, Wallach, D, Kahan, M, Chu, N, Brennan, F, Feldmann, M
Format: Journal article
Language:English
Published: 1995