Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons

The recent generation of induced pluripotent stem cells (iPSCs) from a patient with Parkinson's disease (PD) resulting from triplication of the α-synuclein (SNCA) gene locus allows unprecedented opportunities to explore its contribution to the molecular pathogenesis of PD. We used the double-ni...

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Bibliographic Details
Main Authors: Heman-Ackah, S, Manzano, R, Hoozemans, J, Scheper, W, Flynn, R, Haerty, W, Cowley, S, Bassett, A, Wood, M
Format: Journal article
Language:English
Published: Oxford University Press 2017