Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays

Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays

In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mu...

Popoln opis

Bibliografske podrobnosti
Main Authors: Ajileye, A, Alvarez, N, Merker, M, Walker, T, Akter, S, Brown, K, Moradigaravand, D, Schön, T, Andres, S, Schleusener, V, Omar, S, Coll, F, Huang, H, Diel, R, Ismail, N, Parkhill, J, de Jong, B, Peto, T, Crook, D, Niemann, S, Robledo, J, Smith, E, Peacock, S, Köser, C
Format: Journal article
Jezik:English
Izdano: American Society for Microbiology 2017

Podobne knjige/članki