Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays
In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mu...
| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
American Society for Microbiology
2017
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| _version_ | 1826296050278727680 |
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| author | Ajileye, A Alvarez, N Merker, M Walker, T Akter, S Brown, K Moradigaravand, D Schön, T Andres, S Schleusener, V Omar, S Coll, F Huang, H Diel, R Ismail, N Parkhill, J de Jong, B Peto, T Crook, D Niemann, S Robledo, J Smith, E Peacock, S Köser, C |
| author_facet | Ajileye, A Alvarez, N Merker, M Walker, T Akter, S Brown, K Moradigaravand, D Schön, T Andres, S Schleusener, V Omar, S Coll, F Huang, H Diel, R Ismail, N Parkhill, J de Jong, B Peto, T Crook, D Niemann, S Robledo, J Smith, E Peacock, S Köser, C |
| author_sort | Ajileye, A |
| collection | OXFORD |
| description | In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings. |
| first_indexed | 2024-03-07T04:10:23Z |
| format | Journal article |
| id | oxford-uuid:c7a0d7a0-3872-476b-8c14-99bf8065f7a7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:10:23Z |
| publishDate | 2017 |
| publisher | American Society for Microbiology |
| record_format | dspace |
| spelling | oxford-uuid:c7a0d7a0-3872-476b-8c14-99bf8065f7a72022-03-27T06:46:28ZSome synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assaysJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7a0d7a0-3872-476b-8c14-99bf8065f7a7EnglishSymplectic Elements at OxfordAmerican Society for Microbiology2017Ajileye, AAlvarez, NMerker, MWalker, TAkter, SBrown, KMoradigaravand, DSchön, TAndres, SSchleusener, VOmar, SColl, FHuang, HDiel, RIsmail, NParkhill, Jde Jong, BPeto, TCrook, DNiemann, SRobledo, JSmith, EPeacock, SKöser, CIn this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations. Although these mutations are likely rare globally, they occur in approximately 7% of multidrug-resistant tuberculosis strains in some settings. |
| spellingShingle | Ajileye, A Alvarez, N Merker, M Walker, T Akter, S Brown, K Moradigaravand, D Schön, T Andres, S Schleusener, V Omar, S Coll, F Huang, H Diel, R Ismail, N Parkhill, J de Jong, B Peto, T Crook, D Niemann, S Robledo, J Smith, E Peacock, S Köser, C Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays |
| title | Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays |
| title_full | Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays |
| title_fullStr | Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays |
| title_full_unstemmed | Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays |
| title_short | Some synonymous and nonsynonymous gyrA mutations in Mycobacterium tuberculosis lead to systematic false-positive fluoroquinolone resistance results with the Hain GenoType MTBDRsl assays |
| title_sort | some synonymous and nonsynonymous gyra mutations in mycobacterium tuberculosis lead to systematic false positive fluoroquinolone resistance results with the hain genotype mtbdrsl assays |
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