Induced Foxp3+ T cells colonising tolerated allografts exhibit the hypomethylation pattern typical of mature regulatory T cells
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the gener...
| Asıl Yazarlar: | , , , , , , |
|---|---|
| Materyal Türü: | Journal article |
| Baskı/Yayın Bilgisi: |
Frontiers Media
2016
|