Notch receptor-ligand binding and activation: insights from molecular studies.

Notch receptor-ligand binding and activation: insights from molecular studies.

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The Notch receptor is part of a core signalling pathway which is highly conserved in all metazoan species. It is required for various cell fate decisions at multiple stages of development and in the adult organism, with dysregulation of the pathway associated with genetic and acquired diseases inclu...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Chillakuri, C, Sheppard, D, Lea, S, Handford, P
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2012

Eitemau Tebyg

Notch receptor-ligand binding and activation: Insights from molecular studies
gan: Chillakuri, C, et al.
Cyhoeddwyd: (2012)

Structural analysis uncovers lipid-binding properties of Notch ligands.
gan: Chillakuri, C, et al.
Cyhoeddwyd: (2013)

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
gan: Suckling, R, et al.
Cyhoeddwyd: (2017)

Structural insights into Notch receptor-ligand interactions
gan: Handford, PA, et al.
Cyhoeddwyd: (2018)

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands
gan: Chandramouli R. Chillakuri, et al.
Cyhoeddwyd: (2013-11-01)

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.
gan: Whiteman, P, et al.
Cyhoeddwyd: (2013)

Structural and functional properties of the human notch-1 ligand binding region.
gan: Hambleton, S, et al.
Cyhoeddwyd: (2004)

Examining How O-Fucose and O-Glucose Glycans Affect Notch-Ligand Binding
gan: Takeuchi, H, et al.
Cyhoeddwyd: (2010)

The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
gan: Judith Hounjet, et al.
Cyhoeddwyd: (2021-09-01)

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication
gan: Yi-Zhi Wang, et al.
Cyhoeddwyd: (2024-02-01)

Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies
gan: Redfield, C, et al.
Cyhoeddwyd: (2016)

Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma
gan: Siar, C.H., et al.
Cyhoeddwyd: (2010)

Protocol for Notch-ligand Binding Assays Using Dynabeads
gan: Shogo Sawaguchi, et al.
Cyhoeddwyd: (2017-10-01)

Notch Ligand Binding Assay Using Flow Cytometry
gan: Shweta Varshney, et al.
Cyhoeddwyd: (2017-12-01)

Characterising the Notch-ligand binding interaction, and its modulation by glycosylation
gan: Taylor, P, et al.
Cyhoeddwyd: (2012)

Diversity in Notch ligand-receptor signaling interactions
gan: Rachael Kuintzle, et al.
Cyhoeddwyd: (2025-01-01)

Molecular and cellular analysis of the membrane binding C2 domain of Notch ligands in health and disease
gan: Meng, Y
Cyhoeddwyd: (2021)

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand.
gan: Maxwell Greene, et al.
Cyhoeddwyd: (2016-01-01)

Cis-interactions between Notch and its ligands block ligand-independent Notch activity
gan: William Hunt Palmer, et al.
Cyhoeddwyd: (2014-12-01)

The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling
gan: Martins, T, et al.
Cyhoeddwyd: (2021)

Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor
gan: Chunting Fu, et al.
Cyhoeddwyd: (2024-07-01)

Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
gan: Shuyan Dai, et al.
Cyhoeddwyd: (2022-10-01)

Insights into intercellular receptor-ligand binding kinetics in cell communication
gan: Chenyi An, et al.
Cyhoeddwyd: (2022-06-01)

A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells
gan: Martin Peter Steinbuck, et al.
Cyhoeddwyd: (2018-06-01)

Glycosylation influences the ligand binding activities of mannose receptor.
gan: Su, Y, et al.
Cyhoeddwyd: (2005)

A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.
gan: Daipeng Chen, et al.
Cyhoeddwyd: (2023-01-01)

The Notch Signaling Pathway: Mechanistic Insights in Health and Disease
gan: Yao Meng, et al.
Cyhoeddwyd: (2024-03-01)

Mutual inactivation of Notch receptors and ligands facilitates developmental patterning.
gan: David Sprinzak, et al.
Cyhoeddwyd: (2011-06-01)

PyPLIF HIPPOS-Assisted Prediction of Molecular Determinants of Ligand Binding to Receptors
gan: Enade P. Istyastono, et al.
Cyhoeddwyd: (2021-04-01)

AIP4/Itch regulates Notch receptor degradation in the absence of ligand.
gan: Patricia Chastagner, et al.
Cyhoeddwyd: (2008-07-01)

Editorial: Molecular Insights Into Ligand-Receptor Interactions on the Cell Surface
gan: Laura Marchetti, et al.
Cyhoeddwyd: (2022-05-01)

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
gan: Zhehua Shao, et al.
Cyhoeddwyd: (2022-05-01)

Role of Notch ligands in tumour angiogenesis
gan: Oon, C
Cyhoeddwyd: (2011)

Molecular dynamics simulations of the ligand-binding domain of an N-methyl-D-aspartate receptor.
gan: Kaye, S, et al.
Cyhoeddwyd: (2006)

Derangement model of ligand-receptor binding
gan: Williams Mobolaji
Cyhoeddwyd: (2022-08-01)

Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands
gan: Platt, N, et al.
Cyhoeddwyd: (1998)

Insights into ligand binding to PreQ1 Riboswitch Aptamer from molecular dynamics simulations.
gan: Zhou Gong, et al.
Cyhoeddwyd: (2014-01-01)

The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors
gan: Gaia Pasqualetto, et al.
Cyhoeddwyd: (2018-02-01)

Exploring Flexibility of Progesterone Receptor Ligand Binding Domain Using Molecular Dynamics.
gan: Liangzhen Zheng, et al.
Cyhoeddwyd: (2016-01-01)

Insights into the ligand binding specificity of SREC‐II (scavenger receptor expressed by endothelial cells)
gan: Catherine Wicker‐Planquart, et al.
Cyhoeddwyd: (2021-10-01)