The studies on the mechanism and inhibition of Isocitrate Dehydrogenases
<p>Isocitrate dehydrogenases (IDHs) are human metabolic enzymes producing NADPH (IDH1/2) or NADH (IDH3). IDHs are involved in cancer metabolism and progress; upregulation and mutations to human IDH1/2 that catalyse reduction of 2-oxoglutarate (2OG) to 2-hydroxyglutarate have been identified in...
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| Format: | Thesis |
| Language: | English |
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2022
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