Targeting ATR in DNA damage response and cancer therapeutics
The ataxia telangiectasia and Rad3-related (ATR) plays an important role in maintaining genome integrity during DNA replication through the phosphorylation and activation of Chk1 and regulation of the DNA damage response. Preclinical studies have shown that disruption of ATR pathway can exacerbate t...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2014
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