Mechanism of Polycomb recruitment to CpG islands revealed by inherited disease-associated mutation

Mechanism of Polycomb recruitment to CpG islands revealed by inherited disease-associated mutation

How the transcription repressing complex Polycomb interacts with transcriptional regulators at housekeeping genes in somatic cells is not well understood. By exploiting a CpG island (CGI) point mutation causing a Mendelian disease, we show that DNA binding of activating transcription factor (TF) det...

Полное описание

Библиографические подробности
Главные авторы:	Caputo, VS, Costa, JR, Makarona, K, Georgiou, E, Layton, DM, Roberts, I, Karadimitris, A
Формат:	Journal article
Язык:	English
Опубликовано:	Oxford University Press 2013

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