The molecular basis of filamin binding to integrins and competition with talin.

The ability of adhesion receptors to transmit biochemical signals and mechanical force across cell membranes depends on interactions with the actin cytoskeleton. Filamins are large, actin-crosslinking proteins that connect multiple transmembrane and signaling proteins to the cytoskeleton. Here, we d...

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Bibliographic Details
Main Authors: Kiema, T, Lad, Y, Jiang, P, Oxley, C, Baldassarre, M, Wegener, K, Campbell, I, Ylänne, J, Calderwood, D
Format: Journal article
Language:English
Published: 2006