IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies

IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies

Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n = 376), we identify coexpressed gene modules wi...

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Hlavní autoři: Friedrich, M, Pohin, M, Jackson, MA, Korsunsky, I, Bullers, SJ, Rue-Albrecht, K, Christoforidou, Z, Sathananthan, D, Thomas, T, Ravindran, R, Tandon, R, Peres, RS, Sharpe, H, Wei, K, Watts, GFM, Mann, EH, Geremia, A, Attar, M, Barone, F, Brenner, M, Buckley, CD, Coles, M, Frei, AP, Lassen, KG, Powrie, FM, McCuaig, S, Thomas, L, Collantes, E, Uhlig, HH, Sansom, SN, Easton, A, Raychaudhuri, S, Travis, SP
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2021

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