BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

<p><strong>Background and aims:</strong> In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimenta...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Koppens, MAJ, Davis, H, Valbuena, GN, Mulholland, E, Simmons, A, Nasreddin, N, East, J, Friedrich, M, Antanaviciute, A, Leedham, S
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Elsevier 2021

Antzeko izenburuak

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
nork: Jaeger, E, et al.
Argitaratua: (2012)

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
nork: Jaeger, E, et al.
Argitaratua: (2012)

Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism
nork: Gooding, S, et al.
Argitaratua: (2020)

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
nork: Davis, H, et al.
Argitaratua: (2015)

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
nork: Tomlinson, I, et al.
Argitaratua: (2011)

Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
nork: Ian P M Tomlinson, et al.
Argitaratua: (2011-06-01)

Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway
nork: Shan-shan Yang, et al.
Argitaratua: (2025-03-01)

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
nork: Harnack, C, et al.
Argitaratua: (2019)

Fstl1 antagonizes BMP signaling and regulates ureter development.
nork: Jingyue Xu, et al.
Argitaratua: (2012-01-01)

Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism
nork: Gary Huiming Soh, et al.
Argitaratua: (2020-04-01)

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
nork: Christine Harnack, et al.
Argitaratua: (2019-09-01)

GREM2 inactivation increases trabecular bone mass in mice
nork: Karin H. Nilsson, et al.
Argitaratua: (2024-06-01)

GREM1 is a potential biomarker for the progression and prognosis of bladder cancer
nork: Peng-cheng Jiang, et al.
Argitaratua: (2023-08-01)

Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis
nork: Jia Q. Ng, et al.
Argitaratua: (2023-10-01)

Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
nork: Jianning Chen, et al.
Argitaratua: (2023-07-01)

GREM1 is expressed in the cancer-associated myofibroblasts of basal cell carcinomas.
nork: Hye Sung Kim, et al.
Argitaratua: (2017-01-01)

A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate.
nork: Linda T Doan, et al.
Argitaratua: (2012-01-01)

BMP4 peptide and enoxacin-loaded mesoporous silica nanoparticles direct cell fate and boost bone regeneration during infection
nork: Junhao Sui, et al.
Argitaratua: (2023-07-01)

TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
nork: Huadie Liu, et al.
Argitaratua: (2023-01-01)

Acquisition of neural fate by combination of BMP blockade and chromatin modification
nork: Agnes Lee Chen Ong, et al.
Argitaratua: (2023-10-01)

Acquisition of neural fate by combination of BMP blockade and chromatin modification
nork: Agnes Lee Chen Ong, et al.
Argitaratua: (2023-11-01)

GREM1 may be a biological indicator and potential target of bladder cancer
nork: Qingxin Yu, et al.
Argitaratua: (2024-10-01)

Association Between Plasma Grem1 and Peritoneal Permeability Alterations in Dialysis Patients
nork: Cihan Uysal, et al.
Argitaratua: (2024-02-01)

GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning
nork: Wen Liu, et al.
Argitaratua: (2022-04-01)

BONE MORPHOGENETIC PROTEIN (BMP) PATHWAY DYSREGULATION SUBVERTS ONCOGENE INDUCED SENESCENCE MECHANISMS IN THE SERRATED PATHWAY OF TUMOURIGENESIS
nork: Boitsova, T, et al.
Argitaratua: (2013)

Intestine, heal thyself! Regulating the intestinal epithelial response to injury
nork: Leedham, SJ
Argitaratua: (2020)

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding
nork: Lewis, A, et al.
Argitaratua: (2014)

A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.
nork: Lewis, A, et al.
Argitaratua: (2014)

Demethyleneberberine Alleviates Pulmonary Fibrosis through Disruption of USP11 Deubiquitinating GREM1
nork: Chuang Ge, et al.
Argitaratua: (2024-02-01)

A change in response to Bmp signalling precedes ectodermal fate choice.
nork: Dee, C, et al.
Argitaratua: (2007)

Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis.
nork: Wenjuan Bi, et al.
Argitaratua: (2013-01-01)

A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding
nork: Annabelle Lewis, et al.
Argitaratua: (2014-08-01)

Basolateral BMP signaling in polarized epithelial cells.
nork: Masao Saitoh, et al.
Argitaratua: (2013-01-01)

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
nork: Ulrike Neckmann, et al.
Argitaratua: (2019-11-01)

Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells
nork: Marina Gattiglio, et al.
Argitaratua: (2023-08-01)

Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism
nork: Kristof Nolan, et al.
Argitaratua: (2016-08-01)

Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2
nork: Kenneth N. Grisé, et al.
Argitaratua: (2021-10-01)

BMP-2 Delivery through Liposomes in Bone Regeneration
nork: Noemi Dirzu, et al.
Argitaratua: (2022-01-01)

Apical constriction and epithelial invagination are regulated by BMP activity
nork: Vijay K. Jidigam, et al.
Argitaratua: (2015-12-01)

Features of patients with hereditary mixed polyposis syndrome caused by duplication of GREM1 and implications for screening and surveillance
nork: Lieberman, S, et al.
Argitaratua: (2017)