BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration
<p><strong>Background and aims:</strong> In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimenta...
Үндсэн зохиолчид: | Koppens, MAJ, Davis, H, Valbuena, GN, Mulholland, E, Simmons, A, Nasreddin, N, East, J, Friedrich, M, Antanaviciute, A, Leedham, S |
---|---|
Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
Elsevier
2021
|
Ижил төстэй зүйлс
Ижил төстэй зүйлс
-
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
-н: Jaeger, E, зэрэг
Хэвлэсэн: (2012) -
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
-н: Jaeger, E, зэрэг
Хэвлэсэн: (2012) -
Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism
-н: Gooding, S, зэрэг
Хэвлэсэн: (2020) -
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
-н: Davis, H, зэрэг
Хэвлэсэн: (2015) -
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
-н: Tomlinson, I, зэрэг
Хэвлэсэн: (2011)