Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
Cells exposed to hypoxia, experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide Reductase (RNR) is the only enzyme capable of de novo synthesis of dNTPs. However, oxygen is an essential cofactor for mammalian RNR (RRM1/RRM2 and RRM1/RRM2...
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Published: |
Elsevier
2017
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