Voltage-dependent blockade of normal and mutant muscle sodium channels by benzylalcohol.

1. We studied the effects of benzylalcohol on heterologously expressed wild type (WT), paramyotonia congenita (R1448H) and hyperkalaemic periodic paralysis (M1360V) mutant alpha-subunits of human skeletal muscle sodium channels. 2. Benzylalcohol blocked rested channels at -150 mV membrane potential,...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Haeseler, G, Mamarvar, M, Bufler, J, Dengler, R, Hecker, H, Aronson, J, Piepenbrock, S, Leuwer, M
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: 2000