Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific mono...

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Bibliographic Details
Main Authors: Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Kotecha, A, Walter, T, Wang, J, Fry, E, Stuart, D, Rao, Z
Format: Journal article
Language:English
Published: National Academy of Sciences 2017