Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific mono...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Wang, X, Zhu, L, Dang, M, Hu, Z, Gao, Q, Yuan, S, Sun, Y, Zhang, B, Ren, J, Kotecha, A, Walter, T, Wang, J, Fry, E, Stuart, D, Rao, Z
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	National Academy of Sciences 2017

Eitemau Tebyg

Neutralization mechanisms of two highly potent antibodies against human enterovirus 71
gan: Zhu, L, et al.
Cyhoeddwyd: (2018)

Neutralization mechanisms of two highly potent antibodies against human enterovirus 71
gan: Zhu, L, et al.
Cyhoeddwyd: (2018)

Structure of human Aichi virus and implications for receptor binding
gan: Zhu, L, et al.
Cyhoeddwyd: (2016)

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2
gan: Zhou, D, et al.
Cyhoeddwyd: (2018)

Electrochemical recognition of charged and neutral guest species by redox-active receptor molecules
gan: Beer, P, et al.
Cyhoeddwyd: (1998)

NEW CLASSES OF ANION RECEPTOR-CONTAINING CHARGED AND NEUTRAL TRANSITION-METAL LEWIS ACIDIC RECOGNITION SITES
gan: Beer, P, et al.
Cyhoeddwyd: (1993)

Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
gan: Zhao, Y, et al.
Cyhoeddwyd: (2020)

Hepatitis A virus capsid structure
gan: Stuart, D, et al.
Cyhoeddwyd: (2018)

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.
gan: Jennifer A Jenks, et al.
Cyhoeddwyd: (2023-01-01)

A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation.
gan: Michelle L Scalley-Kim, et al.
Cyhoeddwyd: (2012-01-01)

Neutral Ferrocenoyl Receptors for the Selective Recognition and Sensing of Anionic Guests.
gan: Beer, P, et al.
Cyhoeddwyd: (1997)

Human immunodeficiency viruses: neutralization and receptors.
gan: Weiss, R, et al.
Cyhoeddwyd: (1988)

Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
gan: Kim, H, et al.
Cyhoeddwyd: (2013)

Characterization of the Interaction of Nerve Agent Mimics with Selected Synthetic Receptors
gan: Carolina Braga Barbosa, et al.
Cyhoeddwyd: (2022-10-01)

Hepatitis A virus and the origins of picornaviruses.
gan: Wang, X, et al.
Cyhoeddwyd: (2015)

Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor.
gan: Kim, H, et al.
Cyhoeddwyd: (2014)

Anion recognition in water by charge-neutral halogen and chalcogen bonding foldamer receptors
gan: Borissov, A, et al.
Cyhoeddwyd: (2019)

Recognition site modifiable tetrapodal receptor and the effect of alkane chains on monosaccharide recognition
gan: Nana Chen, et al.
Cyhoeddwyd: (2024-05-01)

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
gan: Julien J, et al.
Cyhoeddwyd: (2012-09-01)

Structure and receptor binding.
gan: Jackson, T, et al.
Cyhoeddwyd: (2003)

Specific interactions between human integrin alpha v beta 3 and chimeric hepatitis B virus core particles bearing the receptor-binding epitope of foot-and-mouth disease virus.
gan: Sharma, A, et al.
Cyhoeddwyd: (1997)

SELECTIVE ELECTROCHEMICAL RECOGNITION OF THE DIHYDROGEN PHOSPHATE ANION IN THE PRESENCE OF HYDROGEN SULFATE AND CHLORIDE-IONS BY NEW NEUTRAL FERROCENE ANION RECEPTORS
gan: Beer, P, et al.
Cyhoeddwyd: (1993)

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite
gan: Laura-Oana Albulescu, et al.
Cyhoeddwyd: (2019-07-01)

Novel Site-Specific Fatty Chain-Modified GLP-1 Receptor Agonist with Potent Antidiabetic Effects
gan: Xia Zhong, et al.
Cyhoeddwyd: (2019-02-01)

Anion recognition and sensing by neutral and charged transition metal co-ordinated ferrocene phosphine amide receptors
gan: Kingston, J, et al.
Cyhoeddwyd: (1999)

Discovery and Identification of Pyrazolopyramidine Analogs as Novel Potent Androgen Receptor Antagonists
gan: Lingyan Wang, et al.
Cyhoeddwyd: (2018-08-01)

Synthetic Cannabinoid Receptor Agonist ‘JWH-018’ does not mimic Serotonin
gan: Adam Pottsa, et al.
Cyhoeddwyd: (2022-07-01)

Water-soluble macrocyclic receptors for small neutral guests
gan: Huuskonen, J, et al.
Cyhoeddwyd: (1999)

Mechanisms of electrochemical recognition of cations, anions and neutral guest species by redox-active receptor molecules
gan: Beer, P, et al.
Cyhoeddwyd: (1999)

A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic
gan: Dohle, W, et al.
Cyhoeddwyd: (2019)

Receptors for the recognition and extraction of lithium
gan: Jianfeng Zhang, et al.
Cyhoeddwyd: (2023-11-01)

A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding
gan: Jing Yang, et al.
Cyhoeddwyd: (2022-05-01)

Host Factors Modulate Virus-Induced IFN Production via Pattern Recognition Receptors
gan: Wang J, et al.
Cyhoeddwyd: (2024-06-01)

Vorolanib, a novel tyrosine receptor kinase receptor inhibitor with potent preclinical anti-angiogenic and anti-tumor activity
gan: Chris Liang, et al.
Cyhoeddwyd: (2022-03-01)

Contributions of different anthropogenic volatile organic compound sources to ozone formation at a receptor site in the Pearl River Delta region and its policy implications
gan: Z. He, et al.
Cyhoeddwyd: (2019-07-01)

A structural basis for immunodominant human T cell receptor recognition.
gan: Stewart-Jones, G, et al.
Cyhoeddwyd: (2003)

A human monoclonal antibody binds within the poliovirus receptor-binding site to neutralize all three serotypes
gan: Andrew J. Charnesky, et al.
Cyhoeddwyd: (2023-10-01)

Apomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors
gan: Akihiko Miyauchi, et al.
Cyhoeddwyd: (2024-02-01)

Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists
gan: Ayana Yoshihara, et al.
Cyhoeddwyd: (2022-01-01)

Discovery of Kynurenines Containing Oligopeptides as Potent Opioid Receptor Agonists
gan: Edina Szűcs, et al.
Cyhoeddwyd: (2020-02-01)