Selective deactivation of serum IgG: A general strategy for the enhancement of monoclonal antibody receptor interactions
Serum IgG is a potent inhibitor of monoclonal antibody (mAb) binding to the cell-surface Fcγ receptors (FcγRs), which mediate cytotoxic and phagocytic effector functions. Here, we show that this competition can be eliminated, selectively, by the introduction to serum of (i) an enzyme that displaces...
| Egile Nagusiak: | , , , , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2012
|
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Selective deactivation of serum IgG: a general strategy for the enhancement of monoclonal antibody receptor interactions.
Argitaratua 2012
Journal article