Interferon-γ couples CD8+ T cell avidity and differentiation during infection

Effective responses to intracellular pathogens are characterized by T cell clones with a broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell clones are selected throughout the response to retain a breadth of avidities remains unclear. Here, we demonstrate tha...

Full description

Bibliographic Details
Main Authors: Uhl, LFK, Cai, H, Oram, SL, Mahale, JN, MacLean, AJ, Mazet, JM, Piccirilli, T, He, AJ, Lau, D, Elliott, T, Gerard, A
Format: Journal article
Language:English
Published: Springer Nature 2023