MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells

Programmed death ligand-1 (PD-L1) is a critical regulator of T cell function contributing to peripheral immune tolerance. Although it has been shown that posttranscriptional regulatory mechanisms control PD-L1 expression in cancer, it remains unknown whether such regulatory loops operate also in non...

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Détails bibliographiques
Auteurs principaux: Yee, D, Shah, K, Coles, M, Sharp, T, Lagos, D
Format: Journal article
Langue:English
Publié: American Society for Biochemistry and Molecular Biology 2017