DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

TNF-alpha and lymphotoxin (LT, TNF-beta) genes are tandemly arranged and map within the MHC centromeric to HLA-B and telomeric to the class III genes. Both cytokines encoded by these genes are potent immunomodulators. On the other hand, some MHC-linked autoimmune diseases are characterized by abnorm...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ:	Nedospasov, SA, Udalova, I, Kuprash, D, Turetskaya, R
Ձևաչափ:	Journal article
Լեզու:	English
Հրապարակվել է:	1991

Նմանատիպ նյութեր

Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes.
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An STS in the human TNF locus located at 6p21.3.
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Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration
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Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α.
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Հրապարակվել է: (2017-01-01)

-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.
‌: Stuber, F, և այլն
Հրապարակվել է: (1995)

Cloning and characteristics of the human genome locus containing genes of a second type of receptor (75 kDa) for tumor necrosis factor and lymphotoxin
‌: Turetskaia, R, և այլն
Հրապարակվել է: (1991)

[Cloning and characteristics of the human genome locus containing genes of a second type of receptor (75 kDa) for tumor necrosis factor and lymphotoxin]
‌: Turetskaia, R, և այլն
Հրապարակվել է: (1991)

Tumor necrosis factor-α and lymphotoxin-α mediate myocardial ischemic injury via TNF receptor 1, but are cardioprotective when activating TNF receptor 2.
‌: Yanqing Zhang, և այլն
Հրապարակվել է: (2013-01-01)

EVALUATION OF INTERLEUKIN-6, LYMPHOTOXIN-α AND TNF-α GENE POLYMORPHISMS IN CHRONIC PERIODONTITIS.
‌: Velitchka Dosseva-Panova, և այլն
Հրապարակվել է: (2015-09-01)

Highly informative typing of the human TNF locus using six adjacent polymorphic markers.
‌: Udalova, I, և այլն
Հրապարակվել է: (1993)

Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide.
‌: Kuprash, D, և այլն
Հրապարակվել է: (1999)

Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage
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Genomic organization and phylogenetic utility of deer mouse (<it>Peromyscus maniculatus</it>) lymphotoxin-alpha and lymphotoxin-beta
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Հրապարակվել է: (2008-10-01)

Increased Thymic B Cells but Maintenance of ThymicStructure, T Cell Differentiation and Negative Selectionin Lymphotoxin-α and TNF Gene-Targeted Mice
‌: Adrian P. Grech, և այլն
Հրապարակվել է: (2000-01-01)

A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-α/β and TNF-α in cultured endothelial cells
‌: Palao Guillermo, և այլն
Հրապարակվել է: (2005-03-01)

The tumor necrosis factor superfamily members TNFSF14 (LIGHT), lymphotoxin β and lymphotoxin β receptor interact to regulate intestinal inflammation
‌: Giles, DA, և այլն
Հրապարակվել է: (2018)

The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation
‌: Daniel A. Giles, և այլն
Հրապարակվել է: (2018-11-01)

Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy
‌: S. А. Nedospasov
Հրապարակվել է: (2023-06-01)

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
‌: Heikenwalder, M, և այլն
Հրապարակվել է: (2008)

Lymphotoxin-sensitive microenvironments in homeostasis and inflammation
‌: Bryant eBoulianne, և այլն
Հրապարակվել է: (2012-07-01)

Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1.
‌: Knight, J, և այլն
Հրապարակվել է: (2004)

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
‌: Clark, T, և այլն
Հրապարակվել է: (2009)

Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist.
‌: Neve, R, և այլն
Հրապարակվել է: (1996)

Arming ColoAd1 with tumor necrosis factor alpha and lymphotoxin alpha
‌: Koelen, J
Հրապարակվել է: (2015)

The effects of tumor necrosis factor (TNF) derivatives on TNF receptors.
‌: Tchorzewski, H, և այլն
Հրապարակվել է: (1993)

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration
‌: C. Colin Brinkman, և այլն
Հրապարակվել է: (2016-06-01)

Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.
‌: Boraska, V, և այլն
Հրապարակվել է: (2009)

Comparison of patterns of expression of tumour necrosis factor, lymphotoxin and interleukin-6 mRNA.
‌: Turner, M, և այլն
Հրապարակվել է: (1988)

Lymphotoxin expression in human and murine renal allografts.
‌: Harald Seeger, և այլն
Հրապարակվել է: (2018-01-01)

Reproductive effects of the tumor necrosis factor (TNF) deficiency in mice
‌: S. O. Maslennikova, և այլն
Հրապարակվել է: (2015-12-01)

Anti-TNF therapy
‌: Udalova, I, և այլն
Հրապարակվել է: (2016)

Soluble lymphotoxin is an important effector molecule in GVHD and GVL.
‌: Markey, K, և այլն
Հրապարակվել է: (2010)

[Genetic polymorphism of the human genome locus containing the tumor necrosis factor gene: ethnic differences in the allele frequency distribution]
‌: Nedospasov, SA, և այլն
Հրապարակվել է: (1993)

Genetic polymorphism of the human genome locus containing the tumor necrosis factor gene: ethnic differences in the allele frequency distribution
‌: Nedospasov, SA, և այլն
Հրապարակվել է: (1993)

Redefining the Role of Lymphotoxin Beta Receptor in the Maintenance of Lymphoid Organs and Immune Cell Homeostasis in Adulthood
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Հրապարակվել է: (2021-07-01)

Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.
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Հրապարակվել է: (2013-03-01)

Lymphotoxins Serve as a Novel Orchestrator in T1D Pathogenesis
‌: Shi-Wei Liu, և այլն
Հրապարակվել է: (2022-06-01)

Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis.
‌: Jadwiga Bienkowska, և այլն
Հրապարակվել է: (2014-01-01)

Functional characterization of rs2229094 (T>C) polymorphism in the tumor necrosis factor locus and lymphotoxin alpha expression in human retina: the Retina 4 project
‌: Pastor-Idoate S, և այլն
Հրապարակվել է: (2017-05-01)

Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
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Հրապարակվել է: (2014-01-01)