Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.
Immature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for "crosspresentation" via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressi...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797094596250959872 |
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| author | Luckashenak, N Schroeder, S Endt, K Schmidt, D Mahnke, K Bachmann, M Marconi, P Deeg, C Brocker, T |
| author_facet | Luckashenak, N Schroeder, S Endt, K Schmidt, D Mahnke, K Bachmann, M Marconi, P Deeg, C Brocker, T |
| author_sort | Luckashenak, N |
| collection | OXFORD |
| description | Immature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for "crosspresentation" via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressing model TSA indicate that this process contributes to tolerance induction of CD8+ T cells, a phenomenon termed "crosstolerance." However, up to now it has been unknown whether "crosstolerance" can also control autoimmune T cells specific for physiological nontransgenic TSA. Here, we showed that a DC-specific deficiency in uptake of apoptotic material inhibits crosspresentation in vivo. This defect allowed the accumulation of fully functional autoreactive CD8+ T cells that could be activated for autoimmune attack in peripheral lymphoid organs. Thus, our data demonstrate the importance of crosstolerance induction by DCs as a vital instrument for controlling self-reactive T cells from the peripheral repertoire and preventing autoimmune disease. |
| first_indexed | 2024-03-07T04:16:11Z |
| format | Journal article |
| id | oxford-uuid:c980c2b4-b474-4b42-b370-7861c77c0a2f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:16:11Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c980c2b4-b474-4b42-b370-7861c77c0a2f2022-03-27T06:59:33ZConstitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c980c2b4-b474-4b42-b370-7861c77c0a2fEnglishSymplectic Elements at Oxford2008Luckashenak, NSchroeder, SEndt, KSchmidt, DMahnke, KBachmann, MMarconi, PDeeg, CBrocker, TImmature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for "crosspresentation" via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressing model TSA indicate that this process contributes to tolerance induction of CD8+ T cells, a phenomenon termed "crosstolerance." However, up to now it has been unknown whether "crosstolerance" can also control autoimmune T cells specific for physiological nontransgenic TSA. Here, we showed that a DC-specific deficiency in uptake of apoptotic material inhibits crosspresentation in vivo. This defect allowed the accumulation of fully functional autoreactive CD8+ T cells that could be activated for autoimmune attack in peripheral lymphoid organs. Thus, our data demonstrate the importance of crosstolerance induction by DCs as a vital instrument for controlling self-reactive T cells from the peripheral repertoire and preventing autoimmune disease. |
| spellingShingle | Luckashenak, N Schroeder, S Endt, K Schmidt, D Mahnke, K Bachmann, M Marconi, P Deeg, C Brocker, T Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. |
| title | Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. |
| title_full | Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. |
| title_fullStr | Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. |
| title_full_unstemmed | Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. |
| title_short | Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. |
| title_sort | constitutive crosspresentation of tissue antigens by dendritic cells controls cd8 t cell tolerance in vivo |
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