Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy

Background: Transcriptional reconfiguration is central to heart failure, the common cause of which is dilated cardiomyopathy (DCM). However, the impact of three-dimensional (3D) chromatin topology on transcriptional dysregulation and pathogenesis in human DCM remains elusive. Methods: We generated...

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Bibliographic Details
Main Authors:	Feng, Y, Cai, L, Hong, W, Zhang, C, Tan, N, Wang, M, Wang, C, Liu, F, Wang, X, Ma, J, Gao, C, Kumar, M, Mo, Y, Geng, Q, Luo, C, Lin, Y, Chen, H, Wang, S-Y, Watson, MJ, Jegga, AG, Pedersen, RA, Fu, J-D, Wang, ZV, Fan, G-C, Sadayappan, S, Wang, Y, Pauklin, S, Huang, F, Huang, W, Jiang, L
Format:	Journal article
Language:	English
Published:	Lippincott, Williams & Wilkins 2022

Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy

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