Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy

Rewiring of 3D chromatin topology orchestrates transcriptional reprogramming and the development of human dilated cardiomyopathy

Background: Transcriptional reconfiguration is central to heart failure, the common cause of which is dilated cardiomyopathy (DCM). However, the impact of three-dimensional (3D) chromatin topology on transcriptional dysregulation and pathogenesis in human DCM remains elusive. Methods: We generated...

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Main Authors: Feng, Y, Cai, L, Hong, W, Zhang, C, Tan, N, Wang, M, Wang, C, Liu, F, Wang, X, Ma, J, Gao, C, Kumar, M, Mo, Y, Geng, Q, Luo, C, Lin, Y, Chen, H, Wang, S-Y, Watson, MJ, Jegga, AG, Pedersen, RA, Fu, J-D, Wang, ZV, Fan, G-C, Sadayappan, S, Wang, Y, Pauklin, S, Huang, F, Huang, W, Jiang, L
Format: Journal article
Language:English
Published: Lippincott, Williams & Wilkins 2022

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