A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
Colorectal cancers are initiated by the accumulation of mutations in the colonic epithelium. Using a spatially structured cell-based model of a colonic crypt, we investigate the likelihood that the progeny of a mutated cell will dominate, or be sloughed out of, a crypt. Our approach is to perform mu...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
2012
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