The role and impact of Del(5q) and TP53 mutations on haematopoietic stem and progenitor cells during the progression of Myelodysplastic Syndrome to Acute Myeloid Leukaemia

The role and impact of Del(5q) and TP53 mutations on haematopoietic stem and progenitor cells during the progression of Myelodysplastic Syndrome to Acute Myeloid Leukaemia

<p>Myelodysplastic Syndromes (MDS) are a heterogeneous group of haematological malignancies characterised by ineffective haematopoiesis and dysplastic bone marrow changes. Patients frequently progress to Acute Myeloid Leukaemia and this is associated with very poor clinical outcomes. This t...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Doolittle, H
Awduron Eraill:	Jacobsen, S
Fformat:	Traethawd Ymchwil
Cyhoeddwyd:	2017

Eitemau Tebyg

Characterising early human lympho-myeloid haematopoietic progenitors and their relationship with acute myeloid leukaemia stem cells
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Cyhoeddwyd: (2018)

TP53 mutation in newly diagnosed acute myeloid leukemia and myelodysplastic syndrome
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TP53 Alterations in Myelodysplastic Syndromes and Acute Myeloid Leukemia
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TP53-mutated myelodysplastic syndrome and acute myeloid leukemia: biology, current therapy, and future directions
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Allogeneic haematopoietic stem cell transplantation with decitabine-containing preconditioning regimen in TP53-mutant myelodysplastic syndromes: A case study
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TP53-MUTATED MYELODYSPLASIA AND ACUTE MYELOID LEUKEMIA
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P1288: UNMANIPULATED PERIPHERAL HAPLOIDENTICAL HAEMATOPOIETIC STEM CELL TRANSPLANT IS AN EFFECTIVE CONSOLIDATIVE STRATEGY FOR HIGH-RISK ACUTE MYELOID LEUKAEMIA AND MYELODYSPLASTIC SYNDROME
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Rare case of myelodysplastic syndrome with near-tetraploidy and TP53 mutation
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Clinical outcomes and characteristics of patients with TP53-mutated myelodysplastic syndromes
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Immunohistochemical pattern of p53 is a measure of TP53 mutation burden and adverse clinical outcome in myelodysplastic syndromes and secondary acute myeloid leukemia
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Cyhoeddwyd: (2018-04-01)

Identification and characterisation of the haematopoietic stem/progenitor cells at risk for leukaemia development following radiation exposure
gan: Verbiest, T
Cyhoeddwyd: (2016)

PB1913: SYNERGISTIC EFFECTS OF DECITABINE AND APR-246 IN TP53 P.248Q-MUTATED MYELODYSPLASTIC SYNDROME
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Single-molecule DNA sequencing of acute myeloid leukemia and myelodysplastic syndromes with multiple TP53 alterations
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Azacitidine for the treatment of myelodysplastic syndrome, chronic myelomonocytic leukaemia and acute myeloid leukaemia
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Bladder Myeloid Sarcoma with TP53 mutated Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap syndrome: Response to Decitabine-Venetoclax regimen
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Outcomes of allogeneic haematopoietic stem cell transplantation for paediatric patients with MLL-rearranged acute myeloid leukaemia
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Allogeneic Haematopoietic Stem Cell Transplantation for Chronic Myeloid Leukaemia in the Era of Tyrosine Kinase Inhibitors
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Microcosting analysis of haematopoietic stem cell transplantation and chemotherapy with intermediate doses of cytarabine in the treatment of acute myeloid leukaemia
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hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia.
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TP53 Mutations in Acute Myeloid Leukemia: Still a Daunting Challenge?
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Impact of TP53 mutations in acute myeloid leukemia patients treated with azacitidine.
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Cyhoeddwyd: (2020-01-01)

Impact of TP53 mutations in acute myeloid leukemia patients treated with azacitidine
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Cyhoeddwyd: (2020-01-01)

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups
gan: Haase, D, et al.
Cyhoeddwyd: (2019)

To target the untargetable: elucidation of synergy of APR-246 and azacitidine in TP53 mutant myelodysplastic syndromes and acute myeloid leukemia
gan: David A. Sallman
Cyhoeddwyd: (2020-06-01)

Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with TP53 disruptions
gan: Shyam A. Patel, et al.
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Acute Lymphoblastic Leukaemia in the Youngest: Haematopoietic Stem Cell Transplantation and Beyond
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Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia.
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Cyhoeddwyd: (2004)

INVESTIGATION OF THE IMPACT OF THE R248Q MUTATION IN THE TP53 GENE ON THE INTERACTION OF THE P53 PROTEIN WITH THE DRUG APR-246 IN ACUTE MYELOID LEUKEMIA
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Cyhoeddwyd: (2024-10-01)

Recruiting TP53 to target chronic myeloid leukemia stem cells
gan: Steven Grant
Cyhoeddwyd: (2020-05-01)

P471: POLO-LIKE KINASE 4 INHIBITION INDUCED ANTI-LEUKAEMIC EFFECTS THROUGH HISTONE MODIFICATION IN TP53 MUTATED ACUTE MYELOID LEUKAEMIA
gan: Wing Lam, et al.
Cyhoeddwyd: (2023-08-01)

What have we learned about TP53-mutated acute myeloid leukemia?
gan: Moazzam Shahzad, et al.
Cyhoeddwyd: (2024-11-01)