Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers

Native-like trimers of the SOSIP design are being developed as immunogens in human immunodeficiency virus type 1 (HIV-1) vaccine development programs. These trimers display the epitopes for multiple broadly neutralizing antibodies (bNAbs), but can also expose binding sites for some types of non-neut...

Full description

Bibliographic Details
Main Authors: Ringe, RP, Ozorowski, G, Rantalainen, K, Struwe, WB, Matthews, K, Torres, JL, Yasmeen, A, Cottrell, CA, Ketas, TJ, LaBranche, CC, Montefiori, DC, Cupo, A, Crispin, M, Wilson, IA, Ward, AB, Sanders, RW, Klasse, PJ, Moore, JP
Format: Journal article
Language:English
Published: American Society for Microbiology 2017