Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

We generated a transgenic mouse model expressing the apical hypertrophic cardiomyopathy-causing mutation ACTC E99K at 50% of total heart actin and compared it with actin from patients carrying the same mutation. The actin mutation caused a higher Ca(2+) sensitivity in reconstituted thin filaments me...

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Detaylı Bibliyografya
Asıl Yazarlar:	Song, W, Dyer, E, Stuckey, D, Copeland, O, Leung, M, Bayliss, C, Messer, A, Wilkinson, R, Tremoleda, J, Schneider, MD, Harding, SE, Redwood, C, Clarke, K, Nowak, K, Monserrat, L, Wells, D, Marston, S
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2011

Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.

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