Characterisation of the lytic viral peptide LysM and its target, the bacterial Lipid II flippase MurJ

Cell wall synthesis is a highly conserved and essential process in bacteria. The cell wall precursor, Lipid II, is transported across the plasma membrane by the flippase MurJ, a newly discovered putative antibiotic target that is non-redundant in many species. While the mechanism of flipping Lipid I...