Pillar data‐acquisition strategies for cryo‐electron tomography of beam‐sensitive biological samples

For cryo‐electron tomography (cryo‐ET) of beam‐sensitive biological specimens, a planar sample geometry is typically used. As the sample is tilted, the effective thickness of the sample along the direction of the electron beam increases and the signal‐to‐noise ratio concomitantly decreases, limiting...

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Bibliographic Details
Main Authors: Parkhurst, JM, Varslot, T, Dumoux, M, Siebert, CA, Darrow, M, Basham, M, Kirkland, A, Grange, M, Evans, G, Naismith, JH
Format: Journal article
Language:English
Published: International Union of Crystallography 2024