Modulation of osteogenic differentiation in human skeletal cells in Vitro by 5-azacytidine.

Cellular differentiation is controlled by a variety of factors including gene methylation, which represses particular genes as cell fate is determined. The incorporation of 5-azacytidine (5azaC) into DNA in vitro prevents methylation and thus can alter cellular differentiation pathways. Human bone m...

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Bibliographic Details
Main Authors: Locklin, R, Oreffo, R, Triffitt, J
Format: Journal article
Language:English
Published: 1998